NB

Test Items:

Color: White or milky white powder

Appearance: crystalline powder

Odor: Collagen-specific odor,

no odor Protein: ≥95% Average molecular weight: ≤1500

Da Hydroxyproline: ≥8.0%

Moisture content: ≤6.0%

Ash content: ≤3.0%

Cadmium: ≤0.1mg/kg

Pb: ≤0.3mg/kg

Inorganic arsenic: ≤0.5mg/kg

Methyl mercury: ≤0.1mg/kg

Microorganism Total plate count: ≤1000cfu/g

Yeast & mold: ≤30cfu/g

Coli form: Not be detected

Staphylococcus aureus:Not be detected

Pseudomonas aeruginosa: Not be detected

Pathogenic bacteria (Staphylococcus aureus, Salmonella, Shigella): Not be detected

Storage Condition: Store in cool and dry place, avoid sunlight and high temperature.

Collagen Product function:

1. Can protect the skin, make skin flexible

2. Can make bone hard and flexible, not loose fragile

3. Can protect eyes, make cornea transparent

4. Can promote muscle cell connection and make it flexible and loose

5. Can protect and strengthen viscera

6. Collagen also has another important function: improve immune, inhibit cancer cells, activate cells function, treat arthritis and pain, prevent skin aging.

Collagen is regarded as one of the most useful biomaterials. The excellent biocompatibility and safety due to its biological characteristics, such as biodegradability and weak antigenecity, made collagen the primary resource in medical applications. The main applications of collagen as drug delivery systems are collagen shields in ophthalmology, sponges for burns/wounds, mini-pellets and tablets for protein delivery, gel formulation in combination with liposomes for sustained drug delivery, as controlling material for transdermal delivery, and nanoparticles for gene delivery and basic matrices for cell culture systems. It was also used for tissue engineering including skin replacement, bone substitutes, and artificial blood vessels and valves. This article reviews biomedical applications of collagen including the collagen film, which we have developed as a matrix system for evaluation of tissue calcification and for the embedding of a single cell suspension for tumorigenic study. The advantages and disadvantages of each system are also discussed.