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GLUTATHIONE is the most important molecule you need to stay healthy and prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer’s disease. It named as the mother of all antioxidants. Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides and heavy metals.[1] It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side chain and the amine group of cysteine, and the carboxyl group of cysteine is attached by normal peptide linkage to a glycine.
Thiol groups are reducing agents, existing at a concentration around 5 mm in animal cells. Glutathione reduces disulfide bonds formed within cytoplasmic proteins to cysteines by serving as an electron donor. In the process, glutathione is converted to its oxidized form, glutathione disulfide (GSSG), also called L-(–)-glutathione.
Once oxidized, glutathione can be reduced back by glutathione reductase, using NADPH as an electron donor.[2] The ratio of reduced glutathione to oxidized glutathione within cells is often used as a measure of cellular oxidative stress.[3][4]

[1]. ^ Jump up to:a b Couto, Narciso; Malys, Naglis; Gaskell, Simon; Barber, Jill (30 April 2013). "Partition and Turnover of Glutathione Reductase from Saccharomyces cerevisiae: a Proteomic Approach". Journal of Proteome Research. 12 (6): 2885–94. doi:10.1021/pr4001948. PMID 23631642.
[2]. Jump up^ Pastore, Anna; Piemonte, Fiorella; Locatelli, Mattia; Lo Russo, Anna Lo; Gaeta, Laura Maria; Tozzi, Giulia; Federici, Giorgio (August 2001)."Determination of blood total, reduced, and oxidized glutathione in pediatric subjects". Clinical Chemistry. 47 (8): 1467–9. PMID 11468240.
[3]. ^ Jump up to:a b Lu, Shelly C. (1 May 2013). "Glutathione synthesis". Biochimica et Biophysica Acta. 1830 (5): 3143–53. doi:10.1016/j.bbagen.2012.09.008.
[4]. Lu, Shelly C. (1 May 2013). "Glutathione synthesis". Biochimica et Biophysica Acta. 1830 (5): 3143–53. doi:10.1016/j.bbagen.2012.09.008.