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Evaluation of the Chondroprotective Effects of Glucosamine and Fish Collagen Peptide on a Rabbit ACLT Model Using Serum Biomarkers, bellowing shows the test and result.
The aim of this study was to investigate the correlations of severity of osteoarthritis (OA) and serum biomarkers including keratan sulfate (KS), hyaluronic acid (HA) and chondroitin sulfate (CS) 846 epitope. We also investigated the effect of glucosamine and fish collagen peptide (FCP) on OA. OA was induced in 12 rabbits (12 weeks of age) by anterior cruciate ligament transection (ACLT). After the surgery, the rabbits were orally administered FCP (F group), glucosamine (G group) or FCP and glucosamine (FG group) for 4 weeks. The control group was provided water ad libitum (C group). Blood was collected before surgery (pre-ACLT) and before euthanasia (post-ACLT) for serum marker measurement. Macroscopically and histologically.

Fig.1.  From this Fig. Macroscopic evaluation showed mildly eroded condylar surfaces in the C group. Macroscopic findings at 4 weeks post surgery. A, control (C) group; B, fish collagen peptide (F) group; C, glucosamine (G)group; D, fish collagen peptide + glucosamine (FG) group. In the C group, the surface of the condyle has mild cartilage erosions (arrows). However, no erosion was seen in the other groups (F, G, FG).

1) Department of Veterinary Clinical Medicine, Tottori University, 4–101 Koyama-Minami, Tottori 680–8553, Japan
2) R & D Division, Yaizu Suisankagaku Industry Co., Ltd., 5–8–13 Kogawa-Shinmachi, Yaizu 425–8570, Japan
(Received 28 May 2012/Accepted 1 November 2012/Published online in J-STAGE 15 November 2012)