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Type I collagen from fish source

2017-03-16

 

A recently published paper provides the first scientific evidence from a pre-clinical setting using a porcine model, to explain how a Type I collagen dressing may improve wound closure by targeting multiple key mechanisms. (Elgharably 2013) 
Findings show:

  • • Type I collagen served as a neutrophil chemotactic factor, recruiting large number of neutrophils to the wound
  • • Increased macrophage infiltration
  • • Significant increase in endothelial cell abundance
  • • Cell receptors on the triple helix collagen molecule provide a scaffold for cellular attachment eg fibroblasts
  • • Upregulation of collagen Type I gene expression and a significantly increased TypeI:III ratio – this could have significance for the tensile strength of the healed wound and scarring

Increased size of rete ridges demonstrating improved quality of closure